Cyclodextrins are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits joined by α-1,4 glycosidic bonds. Cyclodextrins are produced from starch by enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental engineering.
The natural α-, β- and γ-Cyclodextrin in Pharma (αCD, βCD and γCD) consist of six, seven, and eight glucopyranose units, respectively. The natural Cyclodextrin, in particular βCD, are of limited aqueous solubility meaning that complexes resulting from interaction of lipophiles with these Cyclodextrin in Pharma can be of limited solubility resulting in precipitation of solid Cyclodextrin in Pharma complexes from water and other aqueous systems. In fact, the aqueous solubility of the natural Cyclodextrin is much lower than that of comparable acyclic saccharides. This is thought to be due to relatively strong intermolecular hydrogen bonding in the crystal state. Substitution of any of the hydrogen bond forming hydroxyl groups, even by lipophilic methoxy functions, results in dramatic improvement in their aqueous solubility. Water-soluble Cyclodextrin in Pharma derivatives of commercial interest include the hydroxypropyl derivatives of βCD and γCD, the randomly methylated β-Cyclodextrin in Pharma (RMβCD), and sulfobutylether β-Cyclodextrin in Pharma sodium salt (SBEβCD).
According to the new market research report “Cyclodextrin - Global Market Insights and Sales Trends 2024”, published by QYResearch, the global Cyclodextrin market size is projected to reach USD 0.06 billion by 2029, at a CAGR of 7.6% during the forecast period.
- Global Cyclodextrin MarketSize(US$ Mn), 2018-2029
Source: QYResearch, "Cyclodextrin - Global Market Insights and Sales Trends 2024”
- Global CyclodextrinTop12 Players Ranking and Market Share（Based on data of 2021, Continually updated）
Source: QYResearch, "Cyclodextrin - Global Market Insights and Sales Trends 2024”
The global key manufacturers of Cyclodextrin include Qufu Tianli, Jiangsu Fengyuan, Yunan Yongguang, Shandong Xinda, Mengzhou Hongji, Mengzhou Huaxing, Zibo Qianhui, Roquette, Shandong Xinda, Yunan Yongguang, etc. In 2021, the global top five players had a share approximately 73.0% in terms of revenue.
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