Gas chromatography mass spectrometry (GC-MS) consists of two very different analytical techniques: gas chromatography (GC) which is hyphenated (hence uses a hyphen not a forward slash) to mass spectrometry (MS). Usually, the analytical instrument consists of a gas chromatograph that is hyphenated via a heated transfer line to the mass spectrometer, and the two techniques take place in series.
GC-MS can be used to study liquid, gaseous or solid samples. Analysis begins with the gas chromatograph, where the sample is effectively vaporized into the gas phase and separated into its various components using a capillary column coated with a stationary (liquid or solid) phase. The compounds are propelled by an inert carrier gas such as helium, hydrogen or nitrogen. As components of the mixture are separated, each compound elutes from the column at a different time based on its boiling point and polarity. The time of elution is referred to as a compound's retention time. GC has the capacity to resolve complex mixtures or sample extracts containing hundreds of compounds.
Once the components leave the GC column, they are ionized and fragmented by the mass spectrometer using electron or chemical ionization sources. Ionized molecules and fragments are then accelerated through the instrument’s mass analyzer, which quite often is a quadrupole or ion trap. It is here that ions are separated based on their different mass-to-charge (m/z) ratios. GC-MS data acquisition can be performed in either full scan mode, to cover either a wide range of m/z ratios, or selected ion monitoring (SIM) mode, to gather data for specific masses of interest.
The final steps of the process involve ion detection and analysis, with fragmented ions appearing as a function of their m/z ratios. Peak areas, meanwhile, are proportional to the quantity of the corresponding compound. When a complex sample is separated by GC-MS, it will produce many different peaks in the gas chromatogram and each peak generates a unique mass spectrum used for compound identification. Using extensive commercially available libraries of mass spectra, unknown compounds and target analytes can be identified and quantified.
Gas Chromatography-Mass Spectrometer Market Summary
According to the new market research report “Gas Chromatography-Mass Spectrometer- Global Market Share and Ranking, Overall Sales and Demand Forecast 2024-2030”, published by QYResearch, the global Gas Chromatography-Mass Spectrometer market size is projected to reach USD 0.97 billion by 2030, at a CAGR of 5.6% during the forecast period.
- Global Gas Chromatography-Mass Spectrometer MarketSize(US$ Million), 2019-2030
Source: QYResearch, "Gas Chromatography-Mass Spectrometer- Global Market Share and Ranking, Overall Sales and Demand Forecast 2024-2030”
- Global Gas Chromatography-Mass Spectrometer Top17Players Ranking and Market Share (Ranking is based on the revenue of 2023, continually updated)
Source: QYResearch, "Gas Chromatography-Mass Spectrometer- Global Market Share and Ranking, Overall Sales and Demand Forecast 2024-2030”
According to QYResearch Top Players Research Center, the global key manufacturers of Gas Chromatography-Mass Spectrometer include Agilent Technologies, Shimadzu, ThermoFisher, PerkinElmer, FPI, JEOL, LECO, Anyeep, Bruker, TechComp (SCION), etc. In 2023, the global top five players had a share approximately 67.0% in terms of revenue.
Market Drivers:
Increasing Demand for Analytical Instruments: The growing need for accurate and reliable analytical instruments across various industries, including pharmaceuticals, food and beverage, environmental monitoring, and forensic science, is driving the demand for GC-MS systems.
Rising Concerns About Food Safety and Quality: Stringent regulations and standards related to food safety and quality assurance are driving the adoption of GC-MS systems for the detection and quantification of contaminants, pesticides, mycotoxins, and other harmful substances in food and beverages.
Expanding Pharmaceutical Industry: The pharmaceutical industry relies on GC-MS systems for drug development, quality control, impurity profiling, and pharmacokinetic studies. With the increasing demand for new drugs and biopharmaceuticals, there is a growing need for advanced analytical instruments such as GC-MS.
Environmental Monitoring and Regulatory Compliance: Environmental agencies and regulatory bodies worldwide are increasingly focusing on environmental monitoring and pollution control. GC-MS systems play a crucial role in analyzing air, water, soil, and sediment samples for pollutants, toxic chemicals, and hazardous substances to ensure regulatory compliance and protect public health and the environment.
Technological Advancements: Ongoing technological advancements in GC-MS instrumentation, such as improved sensitivity, resolution, speed, and ease of use, are driving market growth. Manufacturers are developing innovative GC-MS systems with enhanced capabilities, automation, and data analysis software to meet the evolving needs of end-users.
Emerging Applications in Metabolomics and Biomarker Discovery: GC-MS is increasingly being used in metabolomics research and biomarker discovery for disease diagnosis, personalized medicine, and drug development. The expanding applications of GC-MS in healthcare and life sciences present significant growth opportunities for the market.
Restraint:
Cost of Equipment: GC-MS instruments can be expensive to purchase, install, and maintain. The initial investment cost for high-quality GC-MS systems, including the instrument itself, accessories, and software, can be significant, especially for small laboratories or organizations with limited budgets.
Complexity of Operation: GC-MS instruments require specialized training and expertise to operate effectively. Analyzing samples using GC-MS involves multiple steps, including sample preparation, method development, instrument calibration, data acquisition, and data analysis. The complexity of the instrumentation and software can pose challenges for inexperienced users and require ongoing training and support.
Instrument Downtime: Like any analytical instrument, GC-MS systems are susceptible to downtime due to equipment failures, maintenance requirements, and calibration issues. Instrument downtime can disrupt laboratory workflows, delay sample analysis, and impact productivity. It is essential for laboratories to have contingency plans in place to minimize the impact of instrument downtime on operations.
Sample Complexity and Matrix Effects: Analyzing complex samples with GC-MS, such as environmental, food, or biological samples, can pose challenges due to matrix effects, interferences, and co-eluting compounds. Sample preparation techniques, such as extraction and derivatization, may be required to remove interferences and enhance analyte detection. However, these additional steps can increase analysis time, cost, and complexity.
Regulatory Compliance and Standards: Laboratories using GC-MS for regulatory compliance or quality control must adhere to strict regulatory requirements and industry standards. Compliance with regulations such as Good Laboratory Practices (GLP), Good Manufacturing Practices (GMP), and ISO accreditation standards requires rigorous documentation, validation of methods, and adherence to quality assurance protocols.
Emerging Technologies and Competition: The analytical instrumentation market is highly competitive, with continuous advancements in technology and new product introductions. Laboratories may face pressure to adopt newer GC-MS technologies, such as high-resolution MS, to stay competitive and meet evolving customer demands. However, adopting new technologies involves additional costs and risks associated with technology validation and implementation.
Data Management and Interpretation: GC-MS analysis generates large volumes of complex data that require sophisticated data management and interpretation tools. Laboratories must invest in robust data management systems, software solutions, and data analysis workflows to handle and interpret GC-MS data effectively. Data integrity, security, and compliance with data privacy regulations are also important considerations.
About The Authors
| Liu Wang- Lead Author |
| Email: wangliu@qyresearch.com
Tel: +86 15755356372
|
| Ms. Wang has 5 years of industry research experience. She focuses on research related to the industry chain of automotive, consumer goods, software, and services, including auto parts, advanced automotive materials, various popular software, etc. Some research topics include Automotive Air Conditioning Electric Scroll Compressors, Lithium Battery Aluminum Plastic Film, Model-based Development (MBD), Predictive Maintenance Solutions, Webtoons, 3D models, Cloud Gaming Backend Service, Visual Content, DHA from Algae, etc. As an analyst with many years of experience in the consulting industry, she has a keen insight into the industry's market trends and developments and uses data analysis to discover potential market opportunities and threats, providing data support for corporate strategic decisions. |
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